3 cans of tuna per week. Much higher doses for way longer periods of time and saw no change. … Practitioners also report using taurine for 6 weeks or so prior to hair analyses, to boost levels and improve detection. I've been doing some reading on ALA supplementation (Alpha Lipoic Acid, not to be confused with Alpha Lineolic Acid for Omega-3 supplementation). Insights on the Use of α-Lipoic Acid for Therapeutic Purposeshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318Here is a recent paper explaining what the researchers have tried using it for.Edit to add this quote from above paper. Sounds worth checking out. The price of this product is moderate and can even be considered cheap in comparison with similar products. Alpha-lipoic acid is an antioxidant that's in many foods, and it's made naturally in our bodies. Modified citrus pectin plus alginate products have been used successfully to reduce lead and mercury in case studies [39]. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. Alpha lipoic acid or lipoic acid is one of the substances that protect the body from free radical-producing molecules. Alpha‐lipoic acid (ALA) is a naturally occurring dithiol micronutrient which acts as a cofactor for mitochondrial enzyme activity. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. Alpha lipoic acid supplements are becoming increasingly popular with people who are looking to get more antioxidants, combat symptoms of diabetes and diabetic neuropathy, slow the damage done by liver disease or HIV, or to boost brain power. Alpha‐lipoic acid (LA), a potent antioxidant, has been shown to be an effective treatment for diabetic neuropathy when given intravenously. Some make it worse. Alpha-lipoic acid may have been combined with other plants or extracts in a specific preparation to treat … Scientific Name(s): 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 5-(1,2-dithiolan-3-yl) valeric acid, 6,8-thioctic acid Common Name(s): Acetate replacing factor, Alpha-lipoic acid, Biletan, Lipoic acid, Lipoicin, Thioctacid, Thioctan, Thioctic acid Not only animals, but also plants produce chelating compounds [32], and the metallothionein content of foods may affect bioavailability, as well as metabolism of toxic metals [33]. Without Alpha-lipoic acid, free radicals will form a chemical reaction that can lead to the emergence of diseases, such as stroke. It’s made inside the mitochondrion — also known as the powerhouse of cells — where it … Due to its potential antioxidant activity, … ReddIt. garlic [42]) and brassicas (e.g., broccoli [43]) have been suggested for effects on glutathione, with hopes for symptomatic improvement and enhanced excretion. Alpha-lipoic acid is a natural antioxidant that can be found in potatoes, spinach, broccoli, liver, kidney, and yeast. "ALA should be admitted at least 2 hr after eating or if taken before; meal should be taken at least 30 min after ALA administration In addition, it has been suggested that acidic pH of the stomach is favorable for ALA absorption through the gastrum. On a lark I decided to google "alpha lipoic acid and multiple sclerosis," and sure enough, there's some early research indicating that it reduced the speed of brain volume loss in people with secondary progressive MS by 68%. It serves vital functions at the cellular level, such as energy production. The lack of concrete clinical literature is unconcerning to me given the evidence surrounding alpha lipoic acid's structural similarities to tried and true chelators and the lack of financial motivation of pharma to study such a compound. for evidence-based support, only the Cutler Therapy comes up. Studies show it may help with symptoms of diabetes, cancer treatments, and other conditions. What is concerning to me, however, is that the Cutler Therapy purports a half-life of 3 hours where the literature shows a half-life of just over 30 minutes. It may be administered intravenously, in creams, and via nebulizer. Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318. Even if ALA can chelate mercury, it's not a compound that sounds likely to get eliminated afterwards. But lipoic acid declines in your body as you age. It aids the body in breaking down sugar and using it to fuel energy. * Recently, an oral controlled‐release formulation of alpha‐lipoic acid (CRLA) was developed, and a pharmacokinetic study demonstrated that CRLA maintained significant plasma levels for 67% longer than a common quick‐release formulation. As long as you're healthy, the body can produce all the ALA it needs for these purposes. (iv) Cilantro (leaves of Coriandrum sativum), a popular culinary and medicinal herb, gained attention when a soup was reported to enhance mercury excretion following dental amalgam removal, and its use as a chelator remains popular despite limited evidence [46]. Some call it the “universal antioxidant” . Look do your research on it! Nonetheless, people claim moderate success using his regimen. In humans, organic selenium supplementation was beneficial in a controlled trial among 103 mercury-exposed villagers [63]. Has anyone else tried this for neuropathy? I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Glutathione is another potent chelator involved in cellular response, transport, and excretion of metal cations, and is a biomarker for toxic metal overload [29, 30, 31]. I'm intrigued by Lipoic Acid as a potential chelator for mercury, as I suffer from chronic mercury toxicity. In this work, a comparative assessment of the effect of drugs (diazepam, phenibut and its isomers, hopantenic acid, pyritinol, piracetam and Phenotropil) on the indicators of stress-reaction of animals in three models of experimental stress, which received the … Nothing else has helped other than narcotic pain meds or Neurontin, many years ago until the nasty side effects set it and became unable to take any of those drugs. Alpha-lipoic acid is most commonly taken by mouth for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Yes, I've had that exact thing from a. lipoic acid too. Some folks say it helps as it acts as a glucose disposal agent, thus allowing slightly higher carb consumption without exiting ketosis. ALA is also beneficial in combating damages and infections that attack vital organs. Selenium depletion in the face of mercury exposure also depletes seleno-enzymes. A more reasonable dosing regimen would be every 1.5 hours (and given my insomnia, I wake up at this rate anyway), which would result in fluctuations between around 125% and 25% dosing amounts. * It has important characteristics that contribute to liver, nerve, and eye health. The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity and is used to treat people with diabetes. (iv) Glutathione is not recommended to be administered orally as it undergoes digestion; however novel modes of delivery, such as liposomal and prodrug preparations, are emerging [57]. Alpha lipoic acid (ALA) is a naturally-occurring antioxidant within the body, but you can obtain incorporate it in your daily diet in the form of supplements. Tried on and off twice. However, caution is merited regarding soluble fiber; in contrast to the protection offered by insoluble fiber, flaxseed has resulted in increased intestinal absorption of cadmium [38]. Optim-ALA Optimized Alpha Lipoic Acid is a highly bioavailable alpha lipoic acid supplement from Natrium Health, the sister company of Nootropics Depot. Press question mark to learn the rest of the keyboard shortcuts, Lipoic Acid as a potential chelator for mercury, the literature shows a half-life of just over 30 minutes. : (i) Taurine [49, 50, 51] and methionine [52] are sulfur-containing amino acids. On the face of it, selenide might not be compatible with chelation, as the two agents may counter the effectiveness of one another [62]; however, selenium may be incorporated in organic molecules, and organic selenium/mercury complexes may be transported through membranes. What side effects did you experience from Neurontin? CDN$ 35.99 CDN$ 35. That's just a side effect of how it affects people. The selenide ion forms an extremely stable, insoluble compound with mercury, and provides relief of mercurialism symptoms. In animals, it decreased lead absorption into bone, and inhibited the action of the delta-aminolevulinic acid dehydratase (ALAD) enzyme [47]. Clinical experience is that it must be used carefully as it poses particular risks of redistribution of metals. Discussion of nootropics and cognitive enhancers. 99. Alpha-Lipoic Acid. It's not a "detox" reaction or from chelating heavy metals. Yes. Press J to jump to the feed. CDN$ 5.54 shipping. I’ve taken it at 600mg daily and had results within a few days. ALA isn't a drug that stays in your body binding to receptors or whatever until cleared out, it's a nutrient that gets absorbed, metabolized, utilized. Several supplements are also in use to address metal toxicities. Alpha lipoic acid has helped me muscle twitches & neuropathy tremendously. * Has anyone else tried this for neuropathy? Alpha Lipoic Acid: Half Life? Some foods have been suggested to reduce absorption or reabsorption of toxic metals and to support natural detoxification pathways. (v) Selenium is an important essential element, that is present at a broad range of levels across populations. R-Lipoic Acid is the most active isomer of alpha-lipoic acid, which is a versatile antioxidant. Alpha-lipoic acid is a natural protective antioxidant. (iii) N-acetyl-cysteine (NAC), an orally available precursor of cysteine, is a chelator of toxic elements and may stimulate glutathione synthesis, particularly in the presence of vitamins C and E [54, 55, 56]. (ii) Alpha-lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g., vitamins E and C, and reduced glutathione) and has metal-chelating activity. New comments cannot be posted and votes cannot be cast. Lipoic acid, also known as Alpha-Lipoic acid, (ALA, Thioctic acid) is similar in structure and function to a vitamin. I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Small Portable Tv, Rapala Panfish Lures, Realistic Owl Coloring Pages, Split Mung Beans Substitute, Recent Philosophy Papers, Chocolate Cupcake Recipe Allrecipes, " /> 3 cans of tuna per week. Much higher doses for way longer periods of time and saw no change. … Practitioners also report using taurine for 6 weeks or so prior to hair analyses, to boost levels and improve detection. I've been doing some reading on ALA supplementation (Alpha Lipoic Acid, not to be confused with Alpha Lineolic Acid for Omega-3 supplementation). Insights on the Use of α-Lipoic Acid for Therapeutic Purposeshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318Here is a recent paper explaining what the researchers have tried using it for.Edit to add this quote from above paper. Sounds worth checking out. The price of this product is moderate and can even be considered cheap in comparison with similar products. Alpha-lipoic acid is an antioxidant that's in many foods, and it's made naturally in our bodies. Modified citrus pectin plus alginate products have been used successfully to reduce lead and mercury in case studies [39]. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. Alpha lipoic acid or lipoic acid is one of the substances that protect the body from free radical-producing molecules. Alpha‐lipoic acid (ALA) is a naturally occurring dithiol micronutrient which acts as a cofactor for mitochondrial enzyme activity. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. Alpha lipoic acid supplements are becoming increasingly popular with people who are looking to get more antioxidants, combat symptoms of diabetes and diabetic neuropathy, slow the damage done by liver disease or HIV, or to boost brain power. Alpha‐lipoic acid (LA), a potent antioxidant, has been shown to be an effective treatment for diabetic neuropathy when given intravenously. Some make it worse. Alpha-lipoic acid may have been combined with other plants or extracts in a specific preparation to treat … Scientific Name(s): 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 5-(1,2-dithiolan-3-yl) valeric acid, 6,8-thioctic acid Common Name(s): Acetate replacing factor, Alpha-lipoic acid, Biletan, Lipoic acid, Lipoicin, Thioctacid, Thioctan, Thioctic acid Not only animals, but also plants produce chelating compounds [32], and the metallothionein content of foods may affect bioavailability, as well as metabolism of toxic metals [33]. Without Alpha-lipoic acid, free radicals will form a chemical reaction that can lead to the emergence of diseases, such as stroke. It’s made inside the mitochondrion — also known as the powerhouse of cells — where it … Due to its potential antioxidant activity, … ReddIt. garlic [42]) and brassicas (e.g., broccoli [43]) have been suggested for effects on glutathione, with hopes for symptomatic improvement and enhanced excretion. Alpha-lipoic acid is a natural antioxidant that can be found in potatoes, spinach, broccoli, liver, kidney, and yeast. "ALA should be admitted at least 2 hr after eating or if taken before; meal should be taken at least 30 min after ALA administration In addition, it has been suggested that acidic pH of the stomach is favorable for ALA absorption through the gastrum. On a lark I decided to google "alpha lipoic acid and multiple sclerosis," and sure enough, there's some early research indicating that it reduced the speed of brain volume loss in people with secondary progressive MS by 68%. It serves vital functions at the cellular level, such as energy production. The lack of concrete clinical literature is unconcerning to me given the evidence surrounding alpha lipoic acid's structural similarities to tried and true chelators and the lack of financial motivation of pharma to study such a compound. for evidence-based support, only the Cutler Therapy comes up. Studies show it may help with symptoms of diabetes, cancer treatments, and other conditions. What is concerning to me, however, is that the Cutler Therapy purports a half-life of 3 hours where the literature shows a half-life of just over 30 minutes. It may be administered intravenously, in creams, and via nebulizer. Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318. Even if ALA can chelate mercury, it's not a compound that sounds likely to get eliminated afterwards. But lipoic acid declines in your body as you age. It aids the body in breaking down sugar and using it to fuel energy. * Recently, an oral controlled‐release formulation of alpha‐lipoic acid (CRLA) was developed, and a pharmacokinetic study demonstrated that CRLA maintained significant plasma levels for 67% longer than a common quick‐release formulation. As long as you're healthy, the body can produce all the ALA it needs for these purposes. (iv) Cilantro (leaves of Coriandrum sativum), a popular culinary and medicinal herb, gained attention when a soup was reported to enhance mercury excretion following dental amalgam removal, and its use as a chelator remains popular despite limited evidence [46]. Some call it the “universal antioxidant” . Look do your research on it! Nonetheless, people claim moderate success using his regimen. In humans, organic selenium supplementation was beneficial in a controlled trial among 103 mercury-exposed villagers [63]. Has anyone else tried this for neuropathy? I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Glutathione is another potent chelator involved in cellular response, transport, and excretion of metal cations, and is a biomarker for toxic metal overload [29, 30, 31]. I'm intrigued by Lipoic Acid as a potential chelator for mercury, as I suffer from chronic mercury toxicity. In this work, a comparative assessment of the effect of drugs (diazepam, phenibut and its isomers, hopantenic acid, pyritinol, piracetam and Phenotropil) on the indicators of stress-reaction of animals in three models of experimental stress, which received the … Nothing else has helped other than narcotic pain meds or Neurontin, many years ago until the nasty side effects set it and became unable to take any of those drugs. Alpha-lipoic acid is most commonly taken by mouth for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Yes, I've had that exact thing from a. lipoic acid too. Some folks say it helps as it acts as a glucose disposal agent, thus allowing slightly higher carb consumption without exiting ketosis. ALA is also beneficial in combating damages and infections that attack vital organs. Selenium depletion in the face of mercury exposure also depletes seleno-enzymes. A more reasonable dosing regimen would be every 1.5 hours (and given my insomnia, I wake up at this rate anyway), which would result in fluctuations between around 125% and 25% dosing amounts. * It has important characteristics that contribute to liver, nerve, and eye health. The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity and is used to treat people with diabetes. (iv) Glutathione is not recommended to be administered orally as it undergoes digestion; however novel modes of delivery, such as liposomal and prodrug preparations, are emerging [57]. Alpha lipoic acid (ALA) is a naturally-occurring antioxidant within the body, but you can obtain incorporate it in your daily diet in the form of supplements. Tried on and off twice. However, caution is merited regarding soluble fiber; in contrast to the protection offered by insoluble fiber, flaxseed has resulted in increased intestinal absorption of cadmium [38]. Optim-ALA Optimized Alpha Lipoic Acid is a highly bioavailable alpha lipoic acid supplement from Natrium Health, the sister company of Nootropics Depot. Press question mark to learn the rest of the keyboard shortcuts, Lipoic Acid as a potential chelator for mercury, the literature shows a half-life of just over 30 minutes. : (i) Taurine [49, 50, 51] and methionine [52] are sulfur-containing amino acids. On the face of it, selenide might not be compatible with chelation, as the two agents may counter the effectiveness of one another [62]; however, selenium may be incorporated in organic molecules, and organic selenium/mercury complexes may be transported through membranes. What side effects did you experience from Neurontin? CDN$ 35.99 CDN$ 35. That's just a side effect of how it affects people. The selenide ion forms an extremely stable, insoluble compound with mercury, and provides relief of mercurialism symptoms. In animals, it decreased lead absorption into bone, and inhibited the action of the delta-aminolevulinic acid dehydratase (ALAD) enzyme [47]. Clinical experience is that it must be used carefully as it poses particular risks of redistribution of metals. Discussion of nootropics and cognitive enhancers. 99. Alpha-Lipoic Acid. It's not a "detox" reaction or from chelating heavy metals. Yes. Press J to jump to the feed. CDN$ 5.54 shipping. I’ve taken it at 600mg daily and had results within a few days. ALA isn't a drug that stays in your body binding to receptors or whatever until cleared out, it's a nutrient that gets absorbed, metabolized, utilized. Several supplements are also in use to address metal toxicities. Alpha lipoic acid has helped me muscle twitches & neuropathy tremendously. * Has anyone else tried this for neuropathy? Alpha Lipoic Acid: Half Life? Some foods have been suggested to reduce absorption or reabsorption of toxic metals and to support natural detoxification pathways. (v) Selenium is an important essential element, that is present at a broad range of levels across populations. R-Lipoic Acid is the most active isomer of alpha-lipoic acid, which is a versatile antioxidant. Alpha-lipoic acid is a natural protective antioxidant. (iii) N-acetyl-cysteine (NAC), an orally available precursor of cysteine, is a chelator of toxic elements and may stimulate glutathione synthesis, particularly in the presence of vitamins C and E [54, 55, 56]. (ii) Alpha-lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g., vitamins E and C, and reduced glutathione) and has metal-chelating activity. New comments cannot be posted and votes cannot be cast. Lipoic acid, also known as Alpha-Lipoic acid, (ALA, Thioctic acid) is similar in structure and function to a vitamin. I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Small Portable Tv, Rapala Panfish Lures, Realistic Owl Coloring Pages, Split Mung Beans Substitute, Recent Philosophy Papers, Chocolate Cupcake Recipe Allrecipes, " />
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reddit alpha lipoic acid

Therefore, the nutrient alpha lipoic acid should be clinically tested … Acetyl L-Carnitine and Alpha Lipoic Acid is sold by bottles of 60 capsules, containing 650 mg. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. They are rich in membranes, particularly of excitable tissues, and they decrease oxidative stress markers resulting from heavy metal exposure. Lipoic acid also prevents diabetic neuropathy characterized by pain, burning, and stabbing sensations in the extremities. Try taking alpha lipoic acid. Why do you think you have mercury toxicity? A selenium yeast product increased mercury excretion and decreased oxidative stress-related biomarkers, particularly urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine [63]. Garlic prevented cadmium-induced kidney damage [44] and decreased the oxidative damage due to lead in rats [45]. When looking up information about this to gather case studies/evidence/etc. Alpha-lipoic acid is essential for certain enzymatic reactions, but there is no official recommended dietary intake of ALA . Trying to keep its serum levels elevated is a failed proposition, and in fact it doesn't even free-float, rather, it's bound to lipoproteins. Alpha lipoic acid (ALA) is a powerful antioxidant which has been widely used in the treatment of different system diseases, such as cardiovascular and cerebrovascular diseases. 4.5 out of 5 stars 6. Jarrow Formulas R-Alpha Lipoic Acid, Supports Energy, Cardio Vascular Health, 100 mg, 60 Caps. Lipoic acid is unique among other antioxidants because it is both water- and fat-soluble. I haaven't found a thc prodcut that helps, yet. Alpha lipoic acid is given in a dose of 300mg at least twice per day for hepatitis B or C. Alpha lipoic acid (ALA), silymarin, and selenium have been used in combination with success in reducing symptoms and elevated liver enzyme levels (though the viral load was not substantially reduced). https://www.amazon.com/R-Alpha-Lipoic-R-LIPOIC-count-STRENGTH/dp/B01M0QS5C7, There are many studies on its effectiveness available on the pubmed site. Lipoic acid (LA), also known as alpha-lipoic acid (ALA), R-lipoic acid, or thioctic acid, is a disulfide-containing compound , found inside every cell of the body . Given the literature value, dosing according to Cutler Therapy would result in fluctuating between just over 100% and 1% blood levels, obviously suboptimal (and also below the clinical determination for elimination). (i) Dietary fibers from various food products, including bran from grains, as well as fruit, have been evaluated as an alternative or adjunct to chelation therapy, with the aim to interrupt enterohepatic recirculation [34, 35, 36], and to modulate intestinal flora [37], with findings of reduced levels of mercury in the brain and blood. Results from certain studies demonstrate that long-term use of alphalipoic acid has beneficial effects on the development of retinopathy since it halts oxidative damage that can result in modified DNA in the retina. A subreddit for those living with neuropathy. The formula cannot be purchased directly from the manufacturer’s website. This is a substantial difference. Chelation is central to the natural detoxification of heavy metals, via the formation of complexes, particularly with glutathione and other small molecules, and their excretion [20]. This increased influx of tryptophan has been shown to result in an increase in serotonin synthesis. 5) Acetyl L-Carnitine and Alpha Lipoic Acid Price. (ii) Other natural polymers have also been gaining attention as potential adsorbents of heavy metals, such as algal polysaccharides alginate [39] and chlorella [40]. Image: MedMD. Glutathione is an important physiological chelator, and the reduced form of glutathione protects cells from reactive oxygen species (ROS) associated with heavy metals [58, 59, 60, 61]. In accordance with the serotonin theory of depression, it may be possible to treat depression by increasing insulin activity. Alpha-lipoic acid is an organic compound found in all human cells. Because it protects the endothelium, alpha lipoic acid reduces the risk of diabetic vascular disease and kidney disease. The dosage of lyrica prescribed is not giving good results. 300 mg of lipoic acid (of the R form of lipoic acid – see below for more detail) is recommended a day for diabetes management. Press J to jump to the feed. After some research, I suggested she try taking the maximum recommended dose of alpha lipoic acid, which is an antioxidant that affects the brain. Alpha lipoic acid has been used successfully to help control symptoms of eye-related disorders, including vision loss, macular degeneration, retina damage, cataracts, glaucoma and Wilson’s disease. In addition, many alternative practitioners contend that alpha-lipoic acid can prevent or treat a multitude of health conditions, including alcoholic liver disease, HIV, Alzheimer's disease, bipolar disorder, cardiac arrhythmia, high blood pressure, rheumatoid arthritis, premature labor, schizoph… You get small amounts of lipoic acid in your diet from spinach and collard greens, broccoli, beef and organ meats. Being both fat and water-soluble, it is readily absorbed from the gut and crosses cellular and blood-brain membrane barriers [22, 53]. It is widely understood that alpha lipoic acid is manufactured endogenously within the human body and that its presence is essential for aerobic metabolism, or the means by which the body generates energy via breakdown of carbohydrates, amino … She did, and within a few months her memory problems vanished completely. You need to be on R Alpha Lipoic Acid. A year ago my mother started suffering from some pretty obvious, and worrying memory loss. Effect of Alpha-Lipoic Acid Supplementation on Oxidative Stress Markers and Antioxidative Defense … "This may explain why the results of trials are confusing.I'm going to have to change when I take mine. Good luck! R-lipoic acid is the biologically active form of the key ‘mitochondrial antioxidant,’ alpha lipoic acid. But, there are few studies that refer to protective effects and potential mechanisms on traumatic brain injury (TBI). Yes. Optim-ALA Optimized Alpha Lipoic Acid utilizes two of the best, most bioavailable forms of R-ALA paired with sesame extract. A friend was telling me about the antioxidant Alpha Lipoic Acid (ALA), and talking about how it can have anti-inflammatory effects. (iii) Given that toxic metals have a great affinity for sulfur-containing peptides, diets rich in sulfur-containing foods, such as alliums (e.g. If you have confirmed that you have mercury toxicity, get a real chelating agent, preferably one actually backed by clinical evidence, and don't try an unproven treatment that doesn't sound likely to work and could be harmful. Therefore, ALA supplements are preferably taken on an empty stomach to benefit of the acidic stomach pH. Simply Nature's Pure Alpha Lipoic Acid RLA R-LA R-Lipoic S-Lipoic HIGHEST Quality ALA, Better Bioavailability also known as Thioctic Acid 120 Count 4 Month Supply. I'm intrigued by Lipoic Acid as a potential chelator for mercury , as I suffer from chronic mercury toxicity. Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. Alpha lipoic acid (ALA), also known as thioctic acid, is an eight-carbon organosulfur compound derived from caprylic acid (octenoic acid). Alpha-Lipoic acid is commonly referred to as ALA and Thiocitic acid. Despite that fact, there has been a lot of recent interest in using ALA supplements. reddit. ALA has been widely explored as a beneficial nutrient for a variety of bodily functions involving the nervous, cardiovascular, immune and detoxification systems. Symptoms: chronic sleep-maintenance insomnia (frequent (2-5) awakenings and low sleep time (avg 5.5hr rg 3-7hr), fatigue, brain fog, depression, anxiety, History: previously heavy fish diet with periods of >3 cans of tuna per week. Much higher doses for way longer periods of time and saw no change. … Practitioners also report using taurine for 6 weeks or so prior to hair analyses, to boost levels and improve detection. I've been doing some reading on ALA supplementation (Alpha Lipoic Acid, not to be confused with Alpha Lineolic Acid for Omega-3 supplementation). Insights on the Use of α-Lipoic Acid for Therapeutic Purposeshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318Here is a recent paper explaining what the researchers have tried using it for.Edit to add this quote from above paper. Sounds worth checking out. The price of this product is moderate and can even be considered cheap in comparison with similar products. Alpha-lipoic acid is an antioxidant that's in many foods, and it's made naturally in our bodies. Modified citrus pectin plus alginate products have been used successfully to reduce lead and mercury in case studies [39]. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. Alpha lipoic acid or lipoic acid is one of the substances that protect the body from free radical-producing molecules. Alpha‐lipoic acid (ALA) is a naturally occurring dithiol micronutrient which acts as a cofactor for mitochondrial enzyme activity. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. Alpha lipoic acid supplements are becoming increasingly popular with people who are looking to get more antioxidants, combat symptoms of diabetes and diabetic neuropathy, slow the damage done by liver disease or HIV, or to boost brain power. Alpha‐lipoic acid (LA), a potent antioxidant, has been shown to be an effective treatment for diabetic neuropathy when given intravenously. Some make it worse. Alpha-lipoic acid may have been combined with other plants or extracts in a specific preparation to treat … Scientific Name(s): 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 5-(1,2-dithiolan-3-yl) valeric acid, 6,8-thioctic acid Common Name(s): Acetate replacing factor, Alpha-lipoic acid, Biletan, Lipoic acid, Lipoicin, Thioctacid, Thioctan, Thioctic acid Not only animals, but also plants produce chelating compounds [32], and the metallothionein content of foods may affect bioavailability, as well as metabolism of toxic metals [33]. Without Alpha-lipoic acid, free radicals will form a chemical reaction that can lead to the emergence of diseases, such as stroke. It’s made inside the mitochondrion — also known as the powerhouse of cells — where it … Due to its potential antioxidant activity, … ReddIt. garlic [42]) and brassicas (e.g., broccoli [43]) have been suggested for effects on glutathione, with hopes for symptomatic improvement and enhanced excretion. Alpha-lipoic acid is a natural antioxidant that can be found in potatoes, spinach, broccoli, liver, kidney, and yeast. "ALA should be admitted at least 2 hr after eating or if taken before; meal should be taken at least 30 min after ALA administration In addition, it has been suggested that acidic pH of the stomach is favorable for ALA absorption through the gastrum. On a lark I decided to google "alpha lipoic acid and multiple sclerosis," and sure enough, there's some early research indicating that it reduced the speed of brain volume loss in people with secondary progressive MS by 68%. It serves vital functions at the cellular level, such as energy production. The lack of concrete clinical literature is unconcerning to me given the evidence surrounding alpha lipoic acid's structural similarities to tried and true chelators and the lack of financial motivation of pharma to study such a compound. for evidence-based support, only the Cutler Therapy comes up. Studies show it may help with symptoms of diabetes, cancer treatments, and other conditions. What is concerning to me, however, is that the Cutler Therapy purports a half-life of 3 hours where the literature shows a half-life of just over 30 minutes. It may be administered intravenously, in creams, and via nebulizer. Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318. Even if ALA can chelate mercury, it's not a compound that sounds likely to get eliminated afterwards. But lipoic acid declines in your body as you age. It aids the body in breaking down sugar and using it to fuel energy. * Recently, an oral controlled‐release formulation of alpha‐lipoic acid (CRLA) was developed, and a pharmacokinetic study demonstrated that CRLA maintained significant plasma levels for 67% longer than a common quick‐release formulation. As long as you're healthy, the body can produce all the ALA it needs for these purposes. (iv) Cilantro (leaves of Coriandrum sativum), a popular culinary and medicinal herb, gained attention when a soup was reported to enhance mercury excretion following dental amalgam removal, and its use as a chelator remains popular despite limited evidence [46]. Some call it the “universal antioxidant” . Look do your research on it! Nonetheless, people claim moderate success using his regimen. In humans, organic selenium supplementation was beneficial in a controlled trial among 103 mercury-exposed villagers [63]. Has anyone else tried this for neuropathy? I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Glutathione is another potent chelator involved in cellular response, transport, and excretion of metal cations, and is a biomarker for toxic metal overload [29, 30, 31]. I'm intrigued by Lipoic Acid as a potential chelator for mercury, as I suffer from chronic mercury toxicity. In this work, a comparative assessment of the effect of drugs (diazepam, phenibut and its isomers, hopantenic acid, pyritinol, piracetam and Phenotropil) on the indicators of stress-reaction of animals in three models of experimental stress, which received the … Nothing else has helped other than narcotic pain meds or Neurontin, many years ago until the nasty side effects set it and became unable to take any of those drugs. Alpha-lipoic acid is most commonly taken by mouth for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Yes, I've had that exact thing from a. lipoic acid too. Some folks say it helps as it acts as a glucose disposal agent, thus allowing slightly higher carb consumption without exiting ketosis. ALA is also beneficial in combating damages and infections that attack vital organs. Selenium depletion in the face of mercury exposure also depletes seleno-enzymes. A more reasonable dosing regimen would be every 1.5 hours (and given my insomnia, I wake up at this rate anyway), which would result in fluctuations between around 125% and 25% dosing amounts. * It has important characteristics that contribute to liver, nerve, and eye health. The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity and is used to treat people with diabetes. (iv) Glutathione is not recommended to be administered orally as it undergoes digestion; however novel modes of delivery, such as liposomal and prodrug preparations, are emerging [57]. Alpha lipoic acid (ALA) is a naturally-occurring antioxidant within the body, but you can obtain incorporate it in your daily diet in the form of supplements. Tried on and off twice. However, caution is merited regarding soluble fiber; in contrast to the protection offered by insoluble fiber, flaxseed has resulted in increased intestinal absorption of cadmium [38]. Optim-ALA Optimized Alpha Lipoic Acid is a highly bioavailable alpha lipoic acid supplement from Natrium Health, the sister company of Nootropics Depot. Press question mark to learn the rest of the keyboard shortcuts, Lipoic Acid as a potential chelator for mercury, the literature shows a half-life of just over 30 minutes. : (i) Taurine [49, 50, 51] and methionine [52] are sulfur-containing amino acids. On the face of it, selenide might not be compatible with chelation, as the two agents may counter the effectiveness of one another [62]; however, selenium may be incorporated in organic molecules, and organic selenium/mercury complexes may be transported through membranes. What side effects did you experience from Neurontin? CDN$ 35.99 CDN$ 35. That's just a side effect of how it affects people. The selenide ion forms an extremely stable, insoluble compound with mercury, and provides relief of mercurialism symptoms. In animals, it decreased lead absorption into bone, and inhibited the action of the delta-aminolevulinic acid dehydratase (ALAD) enzyme [47]. Clinical experience is that it must be used carefully as it poses particular risks of redistribution of metals. Discussion of nootropics and cognitive enhancers. 99. Alpha-Lipoic Acid. It's not a "detox" reaction or from chelating heavy metals. Yes. Press J to jump to the feed. CDN$ 5.54 shipping. I’ve taken it at 600mg daily and had results within a few days. ALA isn't a drug that stays in your body binding to receptors or whatever until cleared out, it's a nutrient that gets absorbed, metabolized, utilized. Several supplements are also in use to address metal toxicities. Alpha lipoic acid has helped me muscle twitches & neuropathy tremendously. * Has anyone else tried this for neuropathy? Alpha Lipoic Acid: Half Life? Some foods have been suggested to reduce absorption or reabsorption of toxic metals and to support natural detoxification pathways. (v) Selenium is an important essential element, that is present at a broad range of levels across populations. R-Lipoic Acid is the most active isomer of alpha-lipoic acid, which is a versatile antioxidant. Alpha-lipoic acid is a natural protective antioxidant. (iii) N-acetyl-cysteine (NAC), an orally available precursor of cysteine, is a chelator of toxic elements and may stimulate glutathione synthesis, particularly in the presence of vitamins C and E [54, 55, 56]. (ii) Alpha-lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g., vitamins E and C, and reduced glutathione) and has metal-chelating activity. New comments cannot be posted and votes cannot be cast. Lipoic acid, also known as Alpha-Lipoic acid, (ALA, Thioctic acid) is similar in structure and function to a vitamin. I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators.

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